Benefits of Inofolic supplementation
| Main biochemical and clinical benefits of Inofolic | Significance (p) |
|---|---|
| Reduces systolic and diastolic pressure | 0.002 |
| Lowers plasma triglycerides by 52% and total cholesterol by 19% | 0.001 |
| Increases whole body insulin sensitivity (ISIcomp) by 84% | 0.002 |
| Lowers total testosterone by 65% | 0.003 |
| Enhances peak progesterone by 129% | 0.003 |
| Ovulation rate increased to 69.5% compared13with control group of 21% | 0.001 |
| Lowers hirsutism score and reduces severity of acne | 0.003 |
| Benefits during ART | Significance (p) |
|---|---|
| Lowers overall dose of gonadotrophins17 | 0.001 |
| Greater number of oocytes of diameter 15mm during stimulation with significant reduction of immature oocytes | 0.005 |
| Benefits during pregnancy | Significance (p) |
|---|---|
| Reduces incidence of gestational diabetes mellitus | 0.001 |
| Gestational age at delivery is 39.3 weeks vs control of 37.2 | 0.001 |
| Curbs BMI increase from 3.8 in control to 2.3 in MI group | 0.001 |
Very well tolerated
No side effects were reported in the six studies that were part of a systematic review of myo-inositol. These involved nearly 600 women where the treatment group received either 2 or 4 g of myo-inositol daily.
Only a very high dose of 12g or more per day induced side effects. These were mild gastrointestinal side effects such as nausea, flatus and diarrhoea. Severity did not increase with dosage which was raised to 30g/day in one study.